![]() ![]() I posted here asking for advice and people said it was a low enough value (cannot find it now) that it was likely false positive but I did the western blot anyway. Prospective evaluation of an algorithm incorporating HSV-1 serostatus found that 11 of 70 persons with indeterminate HSV-2 ELISAs were Western blot-positive.Ĭlinicians should consider selectively using a higher index value to define Focus ELISA HSV-2 positivity based on either HSV-1 serostatus or clinical circumstances. HSV False Positive Labcorp -Western Blot Hey all, I had the STD panel performed at LabCorp and got a equivocal on HSV-2. Selectively raising the ELISA index value defining HSV-2 positivity from >1.1 to >or=3.0 either among HSV-1-positive men or among those without a history or clinical evidence of genital lesions increased the PPV to >or=93%. Western blot positivity was more common in men without herpes simplex virus type 1 (HSV-1) antibody than in those with HSV-1 antibody (93% vs 76%, P = 0.02) and in men with a history or clinical evidence of genital lesions (88% vs 80%, P = 0.30). That is why the the CDC does not recommend routine screening for herpes in low-risk populations. According to published studies, it is estimated that 65 of those low positive Igg values (under 3.5) in the Elisa test are in fact false positives. Using the Western blot technique in patients with progressive SNHL. Ninety-one (84%) of 108 HSV-2 ELISA-positive sera tested HSV-2 Western blot-positive. 1) In low-risk populations, any Elisa HSV-2 Igg 'positive' value under 3.5 should be considered suspect. Serum antibody tests to anti-68-kD inner ear antigen can aid in identifying these cases. HSV-2 Western blots were then prospectively performed on sequential sera with indeterminate HSV-2 ELISAs. The specifics on the test results say 'HSV-2 IgG Type Specific Confirmation Interpretation. 91 (equivocal) Initial draw date (4 weeks after unprotected sexual encounter) HSV-1 Negative HSV-2 Postive (above high normal) 1. MaLabCorp Results: HSV 1 IgG (Not Tested) HSV 2 IgG, Type Spec: 1.59 Index (Flag H), 0.00-0.90 index HSV, IgM I/II Combination: 1.37 Index (Flag H), 0.00-0. LabCorp performed the tests, and the 'low positive' HSV2 result caused them to run an 'HSV-2 IgG Supplemental Test,' which returned a 'positive' value. However, Ashley-Morrow et al have clearly demonstrated that the HSV-2 IgG Western blot is less sensitive than the HerpeSelect HSV-2 IgG assay for detecting IgG seroconversion following newly acquired HSV-2 infection: the median interval between symptom onset and IgG. HSV-2 Western blots were performed on sera from male sexually transmitted disease clinic patients testing HSV-2 ELISA-positive and used to define a new class of indeterminate HSV-2 ELISA result. Jat 11:57 am 78180 cl5405 Participant Annual STD screening HSV-2 Normal. The HSV-2 IgG Western blot assay has historically been considered the gold standard for identifying HSV-2 IgG reactivity. The objective of this study was to define the positive predictive value (PPV) of the Focus herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assay (ELISA) in a low HSV-2 prevalence population and to develop a new test interpretation algorithm. ![]()
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